Atherogenic index of plasma is associated with poor prognosis in diabetic patients with acute kidney injury
Objective:
To explore the correlation between atherogenic index of plasma (AIP) and all-cause death and renal non-recovery in diabetic patients with acute kidney injury (AKI), highlighting its potential clinical significance.
Key Findings:
- 1046 diabetic patients with AKI were enrolled; average age was 62.40 years, with a male to female ratio of 2:1.
- All-cause mortality was 16.8% and renal non-recovery rate was 69.4%.
- AIP predicted all-cause death (AUC = 0.805) and lack of renal recovery (AUC = 0.782).
- AIP levels were non-linearly associated with risk of all-cause death and renal non-recovery.
- After accounting for death as a competing event, AIP was not significantly associated with renal non-recovery.
Interpretation:
AIP serves as a potential biomarker for mortality risk stratification in diabetic patients with AKI, indicating its importance in clinical assessments, but is not reliable for predicting renal recovery.
Limitations:
- Retrospective design may introduce bias.
- Single-center study limits generalizability.
- Competing risks may affect the interpretation of renal recovery outcomes.
- Potential confounding factors not controlled for in the analysis.
Conclusion:
AIP is non-linearly associated with all-cause death in diabetic patients with AKI, indicating its utility in mortality risk assessment rather than renal recovery prediction, which is crucial for clinical decision-making.
